Graves病及桥本病患者血硒、GSH-Px及甲状腺素水平分析

Analysis of blood selenium, GSH-Px and thyroid hormone level in patients with Graves disease and Hashimoto's disease

目的比较Graves病及桥本病(HHD)患者血硒、谷胱甘肽过氧化物酶(GSH-Px)及甲状腺素水平。方法选择我院2014年9月至2015年9月Graves病患者30例作为Graves病组,HD患者30例作为HD组,另选择健康人30例作为对照组,测定和分析三组受检者的血硒、GSH-Px、促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)、甲状腺TSH受体抗体(TRAb)水平。结果 Graves病组和HD组的硒、GSH-Px分别为(102.37±3.59)μg/L、(108.25±4.25)μg/L以及(212.75±53.26)U/L、(214.24±53.16)U/L,明显低于对照组的(126.96±5.68)μg/L、(390.45±84.63)U/L,差异均有统计学意义(P<0.05);而TRAb、TPO-Ab、TG-Ab分别为(54.24±11.32)IU/m L、(49.82±9.32)IU/L、(53.44±12.34)%和(51.62±12.91)IU/m L、(42.24±8.43)IU/L、(50.57±10.23)%,明显高于对照组的(9.25±3.16)IU/m L、(3.24±1.01)IU/L、(15.45±2.33)%,差异均具有统计学意义(P<0.05);Graves病组与HD组以上各项指标比较差异均无统计学意义(P>0.05)。血硒与TPO-Ab、TRAb、TG-Ab呈负相关(P<0.05),GSH-Px与TPO-Ab、TRAb、TG-Ab呈负相关(P<0.05)。结论 Graves病及桥本病患者的血硒水平偏低,可能影响机体甲状腺激素的正常合成,患者通过补硒可能有利于疾病的好转。

Objective To compare the blood selenium, glutathione peroxidase(GSH-Px) and thyroid hormone levels in patients with Graves disease and Hashimoto’s disease(HD). Methods Thirty patients with Graves disease in our hospital from Sep. 2014 to Sep. 2015 were choose as the Graves group, and thirty patients of HD were selected as the HD group. A the same time, 30 healthy people were enrolled as the control group. The blood selenium, GSH Px, thyroid stimulating hormone(TSH), free thyroxine(FT4), free three iodine thyroid original ammonia acid(FT3), thyroid peroxidase antibody(TPOAb), thyroglobulin antibody(TG-Ab), thyroid TSH receptor antibody(TRAb) levels were measured and analyzed. Results The levels of selenium, GSH-Px in Graves group and HD group were(102.37±3.59) μg/L,(108.25±4.25) μ g/L,(212.75 ± 53.26) μ g/L,(214.24 ± 53.16) μ g/L, which were significantly lower than those in control group[(126.96±5.68) μg/L,(390.45±84.63) U/L, P<0.05]. The levels of TRAb, TPO-Ab, TG-Ab in Graves group and HD group were(54.24 ± 11.32) IU/m L,(49.82 ± 9.32) IU/L,(53.44 ± 12.34)% and(51.62 ± 12.91) IU/m L,(42.24 ± 8.43) IU/L,(50.57 ± 10.23)%, which were significantly higher than those in control group [(9.25 ± 3.16) IU/m L,(3.24 ± 1.01) IU/L,(15.45±2.33)%, P<0.05]. There was no significant difference between the indexes of Graves group and HD group(P>0.05). Blood selenium was negatively correlated with TPO-Ab, TRAb, and TG-Ab(P<0.05). GSH-Px was negatively correlated with TPO-Ab, TRAb and TG-Ab(P<0.05). Conclusion The selenium level of Graves disease and HD patients were significantly lower than healthy people, which may influence the synthesis of thyroid hormone. Therefore, selenium may be beneficial for patients to improve the disease condition.