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MICA/B分子与疾病的相关性及其临床应用的研究进展 被引量：2

Correlation of MICA/B molecule with disease and clinical application of MICA/B molecule
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摘要 MICA/B基因具有高度多态性,所编码蛋白MICA/B是NKG2D的主要配体,而NKG2D在机体免疫监视方面发挥着重要作用。越来越多的研究表明MICA/B与疾病的发生发展有着高度的相关性,因此针对MICA/B具体的表达调控机制及临床应用研究是当前研究的热点,本文对近年来MICA/B分子与疾病的相关性及其临床应用进行综述。 MICA/B is a gene with high polymorphism and encodes protein MICA/B, the main ligand of NKG2 D which plays an important role in immune surveillance. Increasingly studies have showed that MICA/B has a significant correlation with the development of diseases, and the expression and regulation mechanism of MICA/B and its clinical application has become the current hot spot. In this paper, the research progress in this area in recent years were reviewed.
作者 李锋 肖曦 魏小斌
机构地区 中南大学湘雅医学院附属海口医院检验科
出处 《海南医学》 CAS 2016年第17期2825-2827,2828,共4页 Hainan Medical Journal
关键词 MICA/B 疾病 相关性 临床应用 NKG2D MICA/B Disease Correlation Clinical application NKG2D
分类号 R363 [医药卫生—病理学]
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参考文献28

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二级参考文献23

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共引文献17

同被引文献24

引证文献2

二级引证文献5

海南医学
2016年 第17期

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