山良菪碱、奥美拉唑联合阿托品治疗急性胃炎疗效观察

Clinical effect of anisodamine and omeprazole combined with atropine in treatment of patients with acute gastritis

目的观察山良菪碱、奥美拉唑联合阿托品治疗急性胃炎的临床疗效。方法选择2015年6月至2016年1月在我院急诊科接受治疗的急性胃炎患者134例,按照随机数表法分为观察组和对照组各67例,对照组予以山良菪碱和奥美拉唑联合治疗,观察组在此基础上另增用阿托品治疗,治疗7 d后比较两组患者的疗效。结果观察组患者的治疗总有效率为98.51%(66/67),明显高于对照组的89.55%(60/67),差异有统计学意义(P<0.05);观察组患者药物首剂注射有效率为82.09%(55/67),追加注射有效率为92.54%(62/67),均分别高于对照组的65.67%(44/67)、80.60%(54/67),差异均有统计学意义(P<0.05);观察组患者的不良反应总发生率为4.48%(3/67),低于对照组的7.46%(5/67),但差异无统计学意义(P<0.05);治疗后观察组的CD4^+为(39.16±5.82)%,明显高于对照组的(32.58±6.45)%,而CD8^+为(21.58±3.12)%,明显低于对照组的(28.61±4.30)%,差异均有统计学意义(P<0.05)。结论山良菪碱、奥美拉唑联合阿托品治疗急性胃炎患者疗效较好,安全性也较高,还可提升患者的细胞免疫功能,值得临床推广。

Objective To study the clinical effect of anisodamine and omeprazole combined with atropine in treatment of patients with acute gastritis. Methods A total of 134 cases of patients with acute gastritis, who underwent treatment in our hospital from June 2015 to January 2016, were selected and divided into the observation group and the control group according to the digital random table method, with 67 cases in each group. The control group received combined treatment of anisodamine and omeprazole. Based on this, the observation group was added with a comprehensive treatment of atorvastatin. 7 d after the treatment, the efficacy of the two groups were compared. Results The total effective rate of the observation group [98.51%(66/67)] was significantly higher than the control group [89.55%(60/67)], P<0.05. The first drug and add drug effective rate in the observation group [82.09%(55/67), 92.54%(62/67), respectively]were significantly higher than those in the control group [65.67%(44/67), 80.60%(54/67), respectively], P<0.05. There was no significant difference between the observation group [4.48%(3/67)] and the control group [7.46%(5/67)] in the incidence of adverse reactions(P<0.05). After treatment, the CD4^+ of the observation group was significantly higher than that of the control group [(39.16±5.82)% vs(32.58±6.45)%, P<0.05], while CD8^+ was significantly lower than the control group, the difference was statistically significant [(21.58±3.12)% vs(28.61±4.30)%, P<0.05]. Conclusion The curative effect of anisodamine, omeprazole and atropine comprehensive therapy on patients with acute gastritis is good. It’s not only safe, but can also improve the patients’ cellular immune function, which is worthy of clinical application.