干燥综合征肾脏损害患者远期预后及影响因素分析

Analysis of the long-term prognosis and the influencing factors of the patients with renal damage in Sjogren syndrome

目的观察干燥综合征肾脏损害(RISS)患者远期预后,并分析其影响因素,为临床诊疗提供依据。方法应用回顾分析法,选取2005年1月至2006年3月我院肾内科收治的RISS患者80例为研究对象,分析患者的临床资料,以肌酐是否正常评价患者的远期预后,并分析其影响因素。结果 80例患者中79例(98.8%)为肾间质性肾炎,均接受免疫抑制剂治疗。随访患者2~10年,平均(4.5±2.5)年,远期并发症以肾结石、神经精神症状和血液系统肿瘤为主,其中2例患者血肌酐倍增,1例进入终末期肾病。单因素分析显示,年龄、肾小管间质病变慢性化、球蛋白、Ig G、血红蛋白是影响预后的因素。结论 RISS进展缓慢,较少患者出现恶化,年龄、肾小管间质病变慢性化、球蛋白、Ig G、血红蛋白是影响预后的因素。

Objective To study the prognosis of renal involvement in Sj?gren syndrome(RISS), and analyze its influencing factors, to provide the basis for clinical diagnosis and treatment. Methods A total of 80 cases of patients with RISS in Department of Nephrology in our hospital from January 2005 to March 2006 were selected as the research objects.The clinical data of patients was retrospectively analyzed, to assess whether normal creatinine as standard can accurately evaluate the long-term prognosis of the patients and to examine its clinical factors by single factor T. Results Among of the 80 cases, 79 cases(98.8%) were of renal interstitial nephritis, which were all treated with immunosuppressive agents.During the 2-10 years' follow-up, with an average of(4.5±2.5) years, the long term complications were mainly kidney stones, nerve symptoms and blood system tumors. Two patients had doubled blood creatinine level, and one patient had renal disease in the end stage. Single factor analysis showed that age, chronic renal tubulointerstitial lesions, globulin,Ig G and hemoglobin were prognostic factors. Conclusion RISS shows slow progression, and few patients are subjected to deterioration. Age, chronic renal tubulointerstitial lesions, globulin, Ig G and hemoglobin were prognostic factors.