骨钙素在糖代谢中的研究进展

Research progress of osteocalcin in glucose metabolism

骨钙素(Osteocalcin,OC)是成骨细胞分泌并沉积在骨基质中的非胶原蛋白,参与骨的矿化。糖代谢可以影响成骨细胞活性,最近研究发现羧化不全骨钙素(uncarboxylatedostecalcin,uc OC)可以促进小鼠胰岛β细胞增殖,胰岛素分泌,增强胰岛素敏感性,进而调控血糖。在糖尿病人群中也发现骨钙素含量与血糖、胰岛素抵抗等存在相关性,这将有助于在控制血糖领域的研究。

Osteocalcin(OC), secreted by osteoblasts, is a non-collagen protein and deposits in bone matrix, affecting bone mineralization. Glucose metabolism can affect osteoblast function. Recent studies have shown that uncarboxylatedostecalcin(uc OC) can promote mouse islet beta cells proliferation and insulin secretion, increase insulin sensitivity and control blood glucose. The findings of the correlations between osteocalcin content and glucose, insulin resistance in patients with type 2 diabetes mellitus(T2DM) would contribute to the control of blood glucose.