胰腺癌神经浸润机制研究新进展

New progress in the study of the mechanism of perineural invasion in pancreatic cancer

胰腺癌机制复杂,致死率高,至今其疗效仍较差,5年生存率极低。胰腺癌中PNI发生率高,是造成胰腺癌术后局部复发的主要因素,是胰腺癌不良预后因素之一。然而,胰腺癌PNI发生的分子生物学原因仍然不清楚,胰腺组织及周围具神经纤维丰富,是胰腺癌PNI的发生发展的解剖学基础。胰腺癌生长的微环境,癌组织介导的神经重塑,都可能是肿瘤细胞PNI的原因。胰腺癌乏氧微环境、慢性炎性微环境以及高糖微环境的协同作用,形成了复杂的网络调控作用,肿瘤基质及肿瘤微环境的网络调控,使神经与肿瘤细胞之间的相互作用发生和形成了PNI。

Pancreatic cancer is characterized by complex mechanism, high mortality rate, poor treatment effect,and low 5-year survival rate. Perineural invasion(PNI) has a high incidence rate in pancreatic cancer, and it was the main cause of pancreatic cancer after operation. PNI is one of the independent factors of poor prognosis in pancreatic cancer. However, the molecular mechanism of PNI is not clear at present. Abundant nerve fibers in the pancreas gland are the anatomical basis of the occurrence and development of PNI in pancreatic cancer. The microenvironment of tumor growth and the organization of the nerve remodeling mediated by tumor tissue may be the cause of PNI of tumor cells.The synergistic effect among the hypoxic microenvironment of pancreatic cancer, inflammatory microenvironment and high glucose microenvironment forms a complex network regulation and control function. PNI occurs and forms in the interaction between nerve and tumor cells in the tumor stroma and tumor microenvironment.