子痫前期的基因遗传学研究进展

Research progress in genetics of pre-eclampsia

子痫前期是妊娠期特有疾病,不仅影响妊娠期母儿安危,而且还对其存在远期影响。引起子痫前期发生的重要因素包括免疫失衡、胎盘浅着床、氧化应激及血栓形成,而基因因子影响所有这些病理生理机制。基因遗传学方面的研究可能使子痫前期在表现出临床症状前就能被识别到,明确子痫前期的基因学发病机制,可为疾病的预测、预防、治疗提供新的方向和思路。

Pre-eclampsia, a pregnancy-specific condition, not only affects the health of mother and baby during pregnancy, but also has long-term consequences. In this review, we discuss some key factors regarded as important in the development of pre-eclampsia, including immune maladaptation, inadequate placentation, oxidative stress, and thrombosis. Genetic factors influence all of these proposed pathophysiological mechanisms. Genetic research offers an attractive strategy for studying the pathogenesis of pre-eclampsia, as it avoids the ethical and practical difficulties of conducting basic science research during the preclinical phase of pre-eclampsia when the underlying pathological changes occur. Clarifying the pathogenesis of genetics of preeclampsia provide new direction and ideas for disease prediction, prevention and treatment.