哈萨克族原发性高血压患者载脂蛋白B/载脂蛋白AI比值的影响因素

Impact factors of serum apolipoprotein B/AI ratio in essential hypertension of Kazakh

目的探讨影响哈萨克族原发性高血压患者血清载脂蛋白B/载脂蛋白AI(ApoB/ApoA1)比值的相关因素。方法随机选取2013年8月至2015年3月在新疆沙湾县流行病学调查的217例哈萨克族原发性高血压患者,按血清ApoB/ApoA1比值水平分为≥0.9组(89例)与<0.9组(128例),收集两组患者的血压、体质量指数(BMI)、尿酸(UA)、同型半胱氨酸(Hcy)等资料。相关性分析采用Pearson直线相关分析,多因素分析采用Logistic回归分析。结果≥0.9组患者的UA、Hcy、舒张压(DBP)、腰围(WC)、BMI均高于<0.9组,差异均有统计学意义(P<0.05)。ApoB/ApoA1比值与UA、Hcy、腰身比(WHt R)、WC、BMI呈正相关(r分别为0.216、0.217、0.219、0.259、0.162,P<0.05)。Logistic回归分析显示:Hcy、BMI是ApoB/ApoA1比值升高的独立危险因素(OR值分别为1.055、1.133,P<0.05)。结论在哈萨克族原发性高血压患者中,Hcy和BMI与ApoB/ApoA1比值的升高密切相关。

Objective To investigate the impact factors of serum apolipoprotein B/AI(ApoB/ApoA1) ratio in patients with essential hypertension of Kazakh. Methods A total of 217 cases of essential hypertension in Kazakh, who was included in Xinjiang Shawan County epidemiological survey during August 2013 to March 2015, were randomly selected and divided into the ≥0.9 group(n=89) and the <0.9 group(n=128) according to the level of serum apolipoprotein B/AI ratio. Values of blood pressure, body mass index(BMI), uric acid(UA), homocysteine(Hcy) and other indexes of the two groups were measured and compared. Correlation analysis and multivariate analysis were performed using Pearson linear correlation analysisandlogistic regression analysis. Results The levels of UA, Hcy, diastolic blood pressure(DBP), waist circumference(WC), BMI in ≥0.9 group were significantly higher than those in <0.9 group(P<0.05).ApoB/ApoA1 ratio was positively correlated with UA, Hcy, waist-to-height ratio(WHt R), WC and BMI(r=0.216, 0.217,0.219, 0.259, 0.162, respectively, P<0.05). The logistic regression analysis showed that Hcy and BMI were independent risk factors of the increase of ApoB/ApoA1 ratio(OR=1.055, 1.133, respectively, P<0.05). Conclusion Hcy and BMI are closely correlated with the elevation of ApoB/ApoA1 ratio in patients with essential hypertension in Kazaks.