血浆N末端脑钠肽原和尿酸水平与急性冠脉综合征关系的研究进展

Advances in the relationship of serum N-terminal pro-B-type natriuretic peptide levels, uric acid levels with acute coronary syndrome

急性冠脉综合征是指不稳定的冠状动脉粥样硬化斑块破裂或糜烂引起急性血小板聚集、血栓形成而导致心肌缺血坏死的一系列临床综合征,因其致残率和病死率极高,现已逐渐成为严重的社会疾病负担。近年来多项研究表明N末端脑钠肽原和尿酸在急性冠脉综合征的发生发展、诊断治疗、疾病预后都具有重要的价值,且两者水平与冠状动脉造影下冠脉病变的严重程度密切相关。本文主要就两者与急性冠脉综合征的研究进展予以综述。

Acute coronary syndrome refers to a series of clinical syndrome that causes acute platelet aggregation and thrombosis due to the rupture or erosion of unstable coronary atherosclerotic plaque.Due to its extremely high disability rate and mortality rate,it has gradually become a serious social disease burden.In recent years,several studies have shown that N-terminal pro-B-type natriuretic peptide(NT-proBNP)and uric acid have important value in the development,diagnosis,treatment,and prognosis of acute coronary syndrome,and their levels are closely related to degree of coronary artery lesions in coronary angiography.This paper reviews the progress of research on NT-proBNP,uric acid,and acute coronary syndrome.