咪唑斯汀治疗特应性皮炎的疗效及可能机制

Effect of Mizolastine on Atopic Dermatitis and Its Possible Mechanisms

目的:探讨咪唑斯汀治疗特应性皮炎的疗效及可能机制。方法:收集2013年4月至2014年10月在我院门诊收治并确诊为特应性皮炎的患者168例,按入院的顺序随机分为2个组别,对照组81例,观察组87例。结果:观察组治疗1周、2周和3周后痊愈的例数分别为5、42和75例,较对照组多,观察组治疗2周的总有效例数较对照组多,两个组别未出现明显的不良反应。治疗前,两个组别血清IgE、IL-5、TNF-α和IFN-γ与嗜酸粒细胞(EOS)计数无显著差异(P>0.05),治疗2周和4周两个组别的血清IgE、IL-5、TNF-α和IFN-γ与EOS计数显著降低(P<0.05),与对照组比,治疗2周观察组的血清IgE、IL-5、TNF-α和IFN-γ与EOS计数降低显著(P<0.05),治疗4周,观察组的IgE较对照组低,两个组别血清IL-5、TNF-α和IFN-γ与EOS计数无显著差异(P>0.05)。结论:咪唑斯汀治疗特应性皮炎安全有效,可能通过降低血清IL-5、TNF-α和IFN-γ与降低外周血EOS计数而发挥作用。

Objective:To investigate the effect of mizolastine on the treatment of atopic dermatitis and possible mechanisms.Methods:One hundred and sixty-eight cases of atopic dermatitis between April 2013 and October 2014 were enrolled into our study and randomly divided into 2groups:81cases in the control group and 87 cases in mizolastine group.Results:Numbers of cured cases in mizolastine group were 5,42 and 75in the 1st,2nd,and 3rd week,respectivelyly,which were significant higher than those of control group(P<0.05).The total effective cases in mizolastine group were also significantly increased as compared with the control group two weeks post treatment(P<0.05).Meanwhile,no significant adverse reactions were observed in thes two groups.Furthermore,there was no significant difference in serum levels of IgE,IL-5,TNF-αand IFN-γ,as well as EOS(eosinophil)count between the mizolastine and control group before treatment(P>0.05).However,after 2weeks and 4weeks treatment,serum IgE,IL-5,TNF-α,IFN-γand EOS count were greatly decreased both in mizolastine group and in control group(P<0.05);compared with the control group,in mizolastine group,serum IgE,IL-5,TNF-α,IFN-γand EOS count were decreased significantly after 2 weeks of treatment(P<0.05);except IgE,no differences were found in serum IL-5,TNF-αand IFN-γ,as well as EOS count betwe above two groups after4 weeks treatment(P>0.05).Conclusion:The treatment effect of mizolastine on atopic dermatitis by through reducing serum IL-5,TNF-αand IFN-γlevels and decreasing EOS count,meanwhile,without significant side effects.