234例冠状动脉粥样硬化性心脏病患者临床分析

Clinical Analysis in 234 Patients with Coronary Heart Disease

目的:分析了234例冠心病患者临床特点及危险因素,为临床冠心病的防治积累经验。方法:选取2011-2012年间在我院行冠脉造影的324例研究对象,根据冠脉造影结果将研究对象分为冠心病组(n=234)及非冠心病组(n=90)。详细询问高血压病、糖尿病、家族早发心脏病、吸烟及高脂血症等病史。并进行血常规、肝肾功能、尿酸、血脂等生化检查,采用Gensini积分评估患者冠脉病变情况。结果:冠心病组包含更多吸烟、家族早发冠心病、高血压及糖尿病等病史的患者;冠心病组WBC、L%、N%、NLR、PLR、ALT、AST、TG、HDL-C、apoA1、BUN、Cr、UA均显著高于非冠心病组,差异有统计学意义。结论:高血压、糖尿病、高AST、高NLR及高尿酸血症是冠心病患者的独立危险因素;AST、脂蛋白a、HDL-C、NLR是冠心病病变严重程度的危险因素。

Objective:To prevent and treat coronary heart disease(CHD)better,this study aimed to analyze the characteristics and associated risk factors in 234 CHD patients.Methods:A total of 324 subjects received coronary angiography(CAG)were recruited in this study.According to the findings of CAG,subjects were divided into CHD group(n=234)and control group(n=90).Smoking,premature CHD,diabetes,hyperlipemia and hypertension history were collected;Blood,liver function,renal function,uric acid(UA)and lipid profiles were examined;then,Gensini score were calculated to evaluate coronary artery lesions.Results:More smoking,premature CHD,diabetes and hypertension patients included in CHD group.White blood cell(WBC),lymphocyte ratio(L%),neutrophil ratio(N%),neutrophil-to-lymphocyte ratio(NLR),plateletto-lymphocyte ratio(PLR),aspartate aminotransferase(AST),alanine aminotransferase(ALT),triacylglycerol(TG),UA,high-density lipoprotein cholesterol(HDL-C),apolipoprotein A1(apoA1),blood urea nitrogen(BUN)were significantly higher in CHD group than those in control group(P<0.05).Conclusion:Hypertension,diabetes,NLR,AST,UA were independent predictors of CHD;Serum AST,apoA1,HDL-C,NLR were independently risk factors associated with the severity of coronary heart disease(measured by gensini score).