通心络胶囊联合阿托伐他汀治疗缺血性卒中脑动脉狭窄效果分析

Outcomes of Tongxinluo Capsule Combined with Atorvastatin on Cerebral Artery Stenosis in Ischemic Stroke

目的:分析阿托伐他汀联合通心络胶囊治疗缺血性卒中脑动脉狭窄的临床效果。方法:选取2013年5月-2015年8月于中山大学附属第八医院就诊治疗的缺血性卒中患者80例作为研究对象,按随机数表法将研究对象分为对照组及研究组,各40例,对照组接受阿托伐他汀、阿司匹林肠溶片双联治疗,研究组接受阿托伐他汀、阿司匹林肠溶片联合通心络胶囊三联治疗,比较两组患者治疗后的总有效率和不良反应发生率,观察两组治疗前后总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)水平以及C反应蛋白(CRP)、白细胞介素-6(IL-6)、血管狭窄率变化情况。结果:研究组总有效率高于对照组,差异具有显著性(95%vs 80%,P=0.048);研究组与对照组不良反应发生率比较无显著差异(P=0.556)。治疗后,研究组TC、TG、HDL-C、LDL-C、CRP、IL-6均低于对照组,差异有显著性(P=0.000)。研究组治疗后血管狭窄率为(61.14±8.32)%,显著低于治疗前(74.66±11.25)%和对照组治疗后(68.57±7.50)%,差异有显著性(P=0.000)。结论:阿托伐他汀等西药联合通心络胶囊治疗缺血性卒中脑动脉狭窄的临床效果显著,可作为治疗的优选方案并在临床中积极推广使用。

Objective:To analyze the clinical effects of atorvastatin combined with Tongxinluo capsule,a traditional Chinese medicine,in the treatment of cerebral artery stenosis in ischemic stroke.Methods:Eighty patients with ischemic stroke treated in The Eighth Affiliated Hospital of Sun Yat-sen University from May 2013 to August 2015 were selected as the research objects and di-vided into the control group and the research group with 40 cases in each group according to the random number table method.The control group was given atorvastatin and aspirin enteric-coated tablets double therapy while the research group was given atorvastatin,aspirin enteric-coated tablets combined with Tongxinluo capsule triple therapy.The clinical curative effects were compared between the two groups.Results:The total effective rate was 95% in the research group,which was higher than that in the control group with 80% (P=0.048).There were no significant difference in the incidence rate of adverse reactions in the research group and the control group(P=0.556).After treatment,the levels of TC,TG,HDL-C,LDL-C,CRP and IL-6 in the research group were lower than those in the control group(P=0.000).The rate of stenosis after treatment was(61.14±8.32)% in the research group,which was significantly lower than that in the group of before treatment with(74.66±11.25)% and than that in the control group with(68.57±7.50)% (P=0.000).Conclusion:Atorvastatin combined with Tongxinluocapsule have a significant clinical effect in the treatment of artery stenosis in ischemic stroke,which can be taken as the best treatment method to be actively promoted and applied in clinic.