武汉市人乳头状瘤病毒基因分型及不同年龄段亚型分布特征

Genotype and Distribution Characteristics of Human Papillomavirus in Different Age Goups in Wuhan

目的:了解本区妇女人乳头状瘤病毒(HPV)感染状况及HPV亚型分布情况。方法:选取2015年月1至2016年12月在本院妇科门诊就诊的妇科患者共1 160人进行HPV分型检测,分析不同年龄段HPV感染特点。结果:受检者妇女人群HPV感染率(25.09%),其中高危型HPV单一感染率为15.34%(178例),以HPV(52、16、58、39、53、51型)感染率较高,低危型HPV单一感染率为4.13%,以HPV(CP8304、11)感染率比较高。HPV混合型感染率5.60%。随后按年龄对HPV进行分析,发现HPV感染率呈现U型趋势,在<25岁和>54岁年龄组均有较高感染率。而将已检测HPV感染者按年龄分布,25-54岁就诊人数多,HPV感染人数最多,其中35-44岁HPV感染人数居多(30.9%),通过多因素回归分析考虑这与该年龄段人群自我保健意识较高以及经济水平相关。结论:武汉地区人群HPV感染高危亚型以52、16、58、39型常见,低危型以11、81(CP8304)常见,不同年龄段的HPV亚型分布各有不同。HPV总体感染率在不同年龄段均有差异。这可为本区HPV针对性预防提供数据。

Objective:To study human papilloma virus(HPV)genotypes,distribution and its clinical significance.Methods:From Jan.2015 to Dec.2016,all 1 160 samples with vaginal symptoms in Zhongnan Hospital of Wuhan University were detected for HPV genotypes,and infectious characteristics in different ages groups were analyzed.Results:Among 1 160 samples,291 cases showed positive HPV infection(25.08%),of which 178 cases was infected with high-risk HPV.HPV 52,16,58,39,53,51 were the most prevalent high-risk types,and HPV CP8304,11 were seen mostly in low-risk types with HPV.The 35-44 years old group was the highest(30.9%)infected population.Conclusion:Infection of HPV genotypes are different in areas,which may be applied for reasonable screening evidence,as well as basis for prevention and treatment of cervical carcinoma.