淋巴结阴性的胃癌患者复发模式Meta分析

Recurrence Pattern in Node-Negative Gastric Cancer:A Meta-Analysis

目的:系统评价淋巴结阴性的胃癌患者常见复发模式:局部复发、腹膜种植、远处转移的发生率。方法:电子检索Pubmed外文数据库及万方等中文数据库,检索时间均截止于2016年3月,阅读并筛选描述淋巴结阴性的胃癌患者术后复发模式的相关文献。通过Comprehensive Meta analysis(CMA)软件进行单个率的统计学分析,记录淋巴结阴性的胃癌患者常见复发模式发生率。结果:共纳入8篇文献。常见复发模式包括局部复发、腹膜种植、远处转移等,其发生率分别为:33.2%,95%CI(25.1%-42.4%);44.7%,95%CI(37.0%-52.6%);37.0%,95%CI(22.5%-54.4%)。结论:淋巴结阴性的胃癌患者常见复发模式主要是局部复发、腹膜种植、远处转移,制定计划的过程中应根据影响各个复发模式的危险因素尽量降低其发生率,延长患者生存期。

Objective:To systematically review the common recurrent patterns of advanced node-negative gastric cancer after curative resection.Methods:Data was obtained from electronic databases at home and abroad such as Pubmed and Wanfang DATA till March 2016.Then,related literature data described the common recurrent patterns after curative resection was screened.A proportion meta-analysis across the studies was performed for the recurrent patterns incidence after curative resection with the use of Comprehensive Meta analysis(CMA)software.Results:Eight retrospective studies were enrolled,and the common recurrent patterns included locoregional growth,peritoneal seeding,or hematogenous(distant)metastasis.Their incidences were respectively 33.2% with 95%CI(25.1%-42.4%),44.7% with 95%CI(37.0%-52.6%),37.0% with95%CI(22.5%-54.4%).Conclusion:Common recurrent patterns after curative resection are mainly of locoregional growth,peritoneal seeding,or hematogenous(distant)metastasis.Different patterns should be taken into consideration to reduce the incidence and improve the overall survival of patients when the medical plan will be selected.