白细胞介素-17A在宫颈癌中的表达及其与肿瘤血管生成之间的关系

Expression of IL-17A in Cervical Carcinoma and Its Relationship with Tumor Angiogenesis

目的:探讨白细胞介素(IL)-17A在宫颈癌中的表达以及IL-17A与肿瘤血管生成之间的关系。方法:分别收集80例手术切除的宫颈癌组织及其癌旁正常宫颈组织。使用免疫组化方法检测IL-17A和CD31的表达情况。观察IL-17A在宫颈癌组织中的表达以及与肿瘤临床病理特点的相关性;计算微血管密度(MVD),评价IL-17A表达与宫颈癌肿瘤血管生成的关系。结果:IL-17A在宫颈癌组织表达量显著高于癌旁组织(P<0.01),其染色部位主要分布于胞质内;IL-17A的表达与宫颈癌的年龄、组织病理分级、临床分期、淋巴结转移之间并无相关性;CD31在宫颈癌组织表达量显著高于癌旁组织(P<0.05),IL-17A阳性的宫颈癌组织中MVD明显高于IL-17A阴性宫颈癌组织(P<0.01)。结论:IL-17A在宫颈癌组织高表达,可能与宫颈癌血管生成相关,而与宫颈癌患者的年龄、病理分级、临床分期、淋巴结转移无相关性。

Objective:To investigate the expression of IL-17A in cervical cancer and the relationship between IL-17A and tumor angiogenesis.Methods:Eighty samples cases of cervical cancer tissue and its adjacent normal cervical tissues were collected,immunohistochemistry was used to detect the expression of IL-17A and CD31.The correlation of expression of IL-17A in cervical cancer tissues with the clinicopathological features of the tumors were observed.Then,microvessel density(MVD)was calculated,and the relationship between IL-17A expression and angiogenesis in cervical cancer was evaluated.Results:The expression of IL-17A in cervical cancer tissues was significantly higher than that in adjacent tissues(P<0.01);the staining sites were mainly located in the cytoplasm;the expression of IL-17A had no relation to the age,histopathological grade,clinical stage and lymph node metastasis of cervical cancer;the expression of CD31 in cervical cancer was also significantly higher than that in adjacent tissues(P<0.05).In addition,the MVD in IL-17A -positive cervical cancer was significantly higher than that in IL-17A -negative cervical cancer(P<0.01).Conclusion:The high expression of IL-17A may be related to angiogenesis incervical cancer,but not to the age,pathological grade,clinical stage,and lymph node metastasis.