PARP10/ARTD10的功能调节及在肿瘤中的研究进展

Functional regulation of PARP10/ARTD10 and its research progress in tumors

ADP-核糖基化是一种可逆的多功能翻译后修饰,通过ADP-核糖基转移酶(PARP或ARTD),将ADP-核糖从NAD+转移至底物,对生物活性的调节起重要作用,最近已成为DNA和癌症生物学中的重要调节因子,其包括聚-ADP-核糖基化(PARylation)和单-ADP-核糖基化(MARylation)。相对于已经研究的较为广泛的聚-ADP-核糖基化(PARylation),对单-ADP-核糖基化的作用知之甚少。PARP10/ARTD10作为单-ADP-核糖基转移酶亚组的创始成员,最近发现其在DNA修复、细胞增殖、免疫、信号传导、新陈代谢和肿瘤发生等生物过程中发挥着重要作用。在此,笔者讨论了这些新发现并就近几年来国内外对PARP10/ARTD10于细胞内外的功能调节及在肿瘤中的研究进展进行综述。

ADP-ribosylation is a reversible multifunctional post-translational modification that transfers ADP-ribose from NAD+to a substrate via ADP-ribosyltransferase(PARP or ARTD),which plays an important role in the regulation of biological activity.It has recently become an important regulator of DNA and cancer biology,including poly-ADP-ribosylation and mono-ADP-ribosylation.Little is known about the effects of mono-ADP-ribosylation relative to the broader poly-ADP-ribosylation that has been studied.As a founding member of the mono-ADP-ribosyltransferase subgroup,PARP10/ARTD10 has recently been found to play an important role in biological processes such as DNA repair,cell proliferation,immunity,signaling,metabolism,and tumorigenesis.This paper reviewed these new findings on the functional regulation of PARP10/ARTD10 inside and outside the cell in tumors in recent years.