血尿酸水平对慢性心力衰竭患者血压及心功能的影响分析

Effect of Blood Uric Acid Level on Blood Pressure and Heart Function in Patients with Chronic Heart Failure

目的分析血尿酸(UA)水平对慢性心力衰谒(CHF)患者血压及心功能的影响。方法选择我院自2015年1月至2017年12月收治的117例CHF患者,根据NYHA分级程度分为3组,NYHAⅡ级为A组,NYHAⅢ级为B组,NYHAⅣ级为C组,对各组患者UA、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)进行检测,对各组UA水平与LVEF、LVEDD的相关性进行比较。并根据血压水平分为高血压病组、正常组,对其UA水平进行比较。结果三组UA水平对比,差异有统计学意义(P<0.05)。患者血尿酸的水平越高,其LVEDD水平越高,而LVEF水平越低。非高血压组UA水平为(319.93±109.78)μmol/L,明显低于高血压组(451.33±119.86)μmol/L,差异有统计学意义(P<0.05)。结论血尿酸水平升高会加速慢性心衰心功能的恶化,高尿酸血症是高血压的危险因素。

Objective To analyzed of blood uric acid levels on blood pressure and cardiac function in patients with chronic heart failure.Methods The 117 patients with CHF admitted to our hospital from January 2015 to December 2017 were divided into3 groups based on NYHA classification.NYHA II was group A,NYHA Ⅲ was group B,and NYHA Ⅳ was group C.The UA,LVEF(left ventricular ejection fraction),and LVEDD(left ventricular end diastolic diameter)were measured in each group.The correlations between UA levels in each group and LVEF and LVEDD were compared.According to the blood pressure level,they were divided into hypertension group and normal group,and their UA levels were compared.Results The difference of UA levels in the three groups was statistically significant(P<0.05).The higher the level of uric acid in the patient,the higher the LVEDD level and the lower the LVEF level.The level of UA in the non-hypertension group was(319.93±109.78)μmol/L,which was significantly lower than that in the hypertension group(451.33±119.86)μmol/L,and the difference was statistically significant(P<0.05).Conclusion Increased blood uric acid levels accelerate the deterioration of heart function in chronic heart failure,and hyperuricemia is a risk factor for hypertension.