血清二肽基肽酶Ⅳ在COPD患者血清中的水平及诊断价值

Detection levels and diagnostic value of serum dipeptidyl peptidase-Ⅳ in patients with chronic obstructive pulmonary disease

目的探讨血清二肽基肽酶IV在慢性阻塞性肺疾病(COPD)患者血清中的水平及诊断价值。方法选取呼吸内科确诊的COPD患者55例,选择同期院门诊健康体检者52例为对照组,清晨空腹肱静脉抽血,测定FIB、PT、DPPⅣ指标,同时于肺功能仪上测定FEV1、FEV1/FVC、DLCO。结果 COPD组FIB、DPPⅣ水平高于对照组,PT低于对照组(t=31.16、22.29、20.16,P<0.05);COPD组FEV1、FEV1/FVC、DLCO均低于对照组(t=20.12、18.43、19.35,P<0.05);DPPⅣ与PT、FEV1、FEV1/FVC、DLCO负相关关系明显,与FIB正相关关系明显(r=-0.52、-0.57、-0.59、-0.62、0.58,P<0.05);诊断COPD时,DPPⅣ的AUC与FEV1/FVC相近(Z=1.57,P>0.05),DPPⅣ、FEV1/FVC的AUC均高于FEV1、DLCO、FIB、PT(Z=11.78、12.14、13.98、14.67、14.45、15.34、14.23、16.30,P<0.05)。结论 COPD患者血清中DPPⅣ水平高,且与PT、FEV1、FEV1/FVC、DLCO呈负相关关系,与FIB呈正相关;DPPⅣ诊断COPD的AUC与FEV1/FVC相近,适合在临床上推广应用。

Objective To investigate the detection levels and diagnostic value of serum dipeptidyl peptidase-Ⅳin patients with chronic obstructive pulmonary disease(COPD).Methods A total of 55 patients with COPD were enrolled as COPD group,and the other 52 healthy subjects were enrolled as control group.The fasting brachial vein blood specimens were collected to measure the levels of FIB,PT and DPPⅣlevels,meanwhile,the levels of FEV1%,FEV1/FVC and DLCO%were detected by pulmonary function test.Results The levels of FIB and DPPⅣin COPD group were significantly higher than those in control group,however,PT levels were significantly lower than those in control group(P<0.05).The levels of FEV1%,FEV1/FVC and DLCO%in COPD group were significantly lower than those in control group(P<0.05).There was a significantn negative correlation between DPPⅣand PT,FEV1%,FEV1/FVC,DLCO%,and there was a significant positive correlation between DPPⅣand FIB(P<0.05).When diagnosing COPD,the AUC of DPPⅣwas similar to FEV1/FVC(Z=1.57,P>0.05).The AUC of DPPⅣ,FEV1/FVC was higher than that of FEV1%,DLCO%,FIB,PT(P<0.05).Conclusion The serum levels of DPPⅣin patients with COPD are higher,and there is a significant negative correlation between DPPⅣand PT,FEV1%,FEV1/FVC,DLCO%,and there is a significant positive correlation between DPPⅣand FIB.The AUC of DPPⅣin diagnosis of COPD is similar to FEV1/FVC,therefor,which is suitable for application and promotion in clinical practice.