抗孕酮治疗子宫内膜异位症的效果及对患者CA125、E2、P和FSH水平的影响

Therapeutic effects of anti-progesterone treatment on endometriosis and its effects on CA125,E2,P and FSH of patients

目的研究抗孕酮对宫内膜异位症患者的临床治疗效果及和对患者抗原癌125(cancer antigen 125,CA125)、雌二醇(estradiol,E2)、孕酮(Prog,P)和卵泡刺激素(follicle-stimulating hormone,FSH)的影响分析。方法选取2016年1月至2017年6月确诊治疗的子宫内膜异位症患者150例,随机分为丹那唑组和抗孕酮组,每组75例。给予丹那唑组患者口服丹那唑药物治疗,给予抗孕酮组患者米非司酮进行治疗,观察两组患者的治疗前后子宫内膜厚度变化。并提取患者血清和腹腔积液采用酶联免疫吸附试验法和化学发光法检测患者治疗前后的CA125、E2、P和FSH水平,并统计2组患者的治疗总有效率和不良反应发生率。结果抗孕酮组患者治疗后的CA125指标水平显著低于丹那唑组治疗后指标水平(P<0.05);抗孕酮组患者治疗后的E、P、FSH水平均显著低于丹那唑组患者治疗后的指标水平(P<0.05);抗孕酮组患者治疗后的子宫内膜厚度低于丹那唑组患者的子宫内膜厚度,差异有统计学意义(P<0.05);丹那唑组患者的治疗总有效率低于抗孕酮组患者的治疗总有效率且不良反应发生率显著高于抗孕酮组患者的不良反应发生率,差异有统计学意义(P<0.05)。结论抗孕酮在子宫内膜异位症的应用治疗中能够起到很好的恢复和改善作用,且安全性高,值临床推广。

Objective To observe the therapeutic effects of anti-progesterone treatment on endometriosis,and to investigate its effects on cancer antigen 125(CA125),estradiol(E2),progesterone(Prog,P) and follicle-stimulating hormone(FSH) of patients with endometriosis.Methods A total of 150 patients with endometriosis who were diagnosed and treated in our hospital from January 2016 to June 2017 were randomly divided into danazol group and anti-progesterone group,with 75 cases in each group.The patients in danazol group were treated by oral danazol,however,the patients in anti-progesterone group were treated by oral mifepristone.The changes of endometrial thickness before and after treatment were observed in both groups.Moreover the levels of CA125,E2,P and FSH in serum and peritoneal effusion were detected by enzyme-linked immunosorbent assay method and chemiluminescence detection before and after treatment,in addition the total effective rate and incidence of adverse reactions were observed and compared between the two groups.Results After treatment the levels of CA125 in anti-progesterone group were significantly lower than those in danazol group(P<0.05),and the levels of E,P and FSH in anti-progesterone group were significantly lower than those in danazol group(P<0.05).Moreover the endometrial thickness in anti-progesterone group was significantly lower than that in danazol group(P<0.05).The total effective rate in danazol group was significantly lower than that in anti-progesterone group,however, the incidence of adverse reaction in danazol group was significantly higher than that in anti-progesterone group(P<0.05).Conclusion Anti-progesterone can play an important role in the treatment of endometriosis, with good safety,therefor, it is worthy of clinical promotion.