精神创伤后应激障碍患者NE、5-HT及DA的水平变化及意义

The changes and significance of NE,5-HT and DA levels in patients with post-traumatic stress disorder

目的探讨精神创伤后应激障碍患者NE(去甲肾上腺素)、5-HT(5-羟色胺)及DA(多巴胺)水平变化及其意义。方法将2015年1月至2016年3月接诊的精神创伤后应激障碍患者中,选取46例患者作为观察组,另外选择48例正常体检的患者作为对照组。通过检测2组患者NE、5-HT及DA等指标水平变化,分析精神创伤后应激障碍患者的临床反应,为临床诊断和治疗提供依据。结果观察组NE为(298.7±80.1)pg/ml、5-HT为(191.4±92.3)pg/ml、DA为(180.6±70.8)pg/ml,观察组的NE、5-HT及DA水平和对照组相比明显升高,差异有统计学意义(P<0.05);观察组IL-2为(12.3±3.9)pg/ml、IL-6为(16.3±5.7)pg/ml、IL-8为(49.2±21.6)pg/ml、TNF-α为(25.1±10.8)pg/ml,观察组的IL-2、IL-6、IL-8和TNF-α水平明显高于对照组,差异有统计学意义(P<0.05);观察组的HAMD评分总分为(27.8±9.4)分,对照组的HAMD评分总分为(1.9±2.6)分,观察组和对照组相比,HAMD评分明显更高,差异有统计学意义(P<0.05);观察组的HAMA评分总分为(32.6±8.2)分,对照组的HAMD评分总分为(4.5±2.5)分,观察组和对照组相比,HAMA评分明显更高,差异有统计学意义(P<0.05)。结论精神创伤后应激障碍患者,其NE、5-HT及DA水平明显高于正常健康人群,有免疫异常情况,并且患者的焦虑、抑郁症状明显高于正常健康人群,对诊断和治疗精神创伤后应激障碍疾病,有十分重要的作用。

Objective To investigate the changes and significance of NE(norepinephrine),5-HT(5-HT)and DA(dopamine)in patients with post-traumatic stress disorder(PTSD).Methods A total of 46 patients with PTSD who were treated in our hospital from January 2015 to March 2016 were enrolled as observation group,and the other 48 patients who underwent physical examination were enrolled as control group.The changes of NE,5-HT and DA levels were observed and compared between the two groups.Moreover the clinical responses of patients were observed to provide the basis for clinical diagnosis and treatment.Results The levels of NE(298.7±80.1)pg/ml,5-HT(191.4±92.3)pg/ml,DA(180.6±70.8)pg/ml in observation group were increased significantly,as compared with those in control group(P<0.05).Moreover the levels of IL-2(12.3±3.9)pg/ml,IL-6 for(16.3±5.7)pg/ml,IL-8(49.2±21.6)pg/ml,TNF-alpha(25.1±10.8)pg/ml in observation group were significantly higher than those in control group(P<0.05).In addition the HAMD scores in observation group were(27.8±9.4)points,which were significantly higher than those[(1.9±2.6)points]in control group(P<0.05),and the HAMA scores in observation group were(32.6±8.2)points which were significantly higher than those[(4.5±2.5)points]in control group(P<0.05).Conclusion The levels of NE,5-HT and DA in patients with post-traumatic stress disorder are significantly higher than those in healthy people,and incidences of immune abnormality and symptoms of anxiety and depression of patients are significantly higher than those of healthy people,which has important significance in diagnosis and treatment of post-traumatic stress disorder diseases.