含萘结构的新型苦参碱衍生物的合成

Synthesis of Novel Matrine Derivatives Containing Naphthalene Structure

以二异丙基氨基锂和氢化钠为亲核试剂,THF为溶剂,苦参碱和萘类化合物为原料,设计并合成了10个含萘结构的新型苦参碱衍生物[14-萘羟次甲基苦参碱(3a^3c),14-萘甲酰基苦参碱(3g^3j)和14-萘甲烯基苦参碱(3d^3f)],其结构经^(1)H NMR,^(13)C NMR,FT-IR和ESI-MS表征。

Ten novel matrine derivatives containing naphthalene structure,14-naphthalene hydroxyl methyl matrine(3a ~ 3c),14-naphthalene formyl matrine( 3g ~ 3j) and 14-naphthyl methyl alkenyl matrine(3d ~ 3f),were designed and synthesized by reaction of matrine and naphthalene compounds in THF,using LDA and Na H as nucleophilic reagent. The structures were characterized by1 H NMR,13 C NMR,FT-IR and ESI-MS.