慢性肾脏病患者甲状旁腺激素同型半胱氨酸检测的临床意义

Clinical Significance of Detection of Parathyroid Hormone and Homocysteine in Patients with Chronic Kidney Disease

目的:探讨慢性肾脏病患者甲状旁腺激素(PTH)、同型半胱氨酸(Hcy)等指标检测的临床意义。方法:48例慢性肾脏病患者(CKD)按临床诊断分为CKD3期、CKD4期、CKD5期3组,分别检测3组患者的血PTH、Cys C、Hcy、Cr等指标,并进行统计分析。结果:CKD5期组患者血清PTH、Cys C、Hcy、Cr水平均高于CKD4期、CKD3期组,差异均有统计学意义(P <0.05),但CKD4期组患者血清PTH、Cys C、Hcy、Cr水平与CKD3期组相比均无显著性差异(P>0.05)。PTH在CKD5期、CKD4期、CKD3期组阳性率分别为:70.8%、21.4%、20%; Hcy在CKD5期、CKD4期、CKD3期组阳性率分别为:58.3%、7.1%、10%。PTH、Hcy、Cr与Cys C呈正相关(R=0.505、0.855、0.788)。结论:PTH、Hcy等指标联合检测有利于CKD患者疾病的诊断与病情判断,为临床诊疗提供准确的指导。

Objective: To explore the clinical significance of the detection of PTH and Hcy in patients with the chronic kidney disease. Methods: 48 patients with chronic kidney disease (CKD) were divided into three groups: CKD stage 3,CKD stage 4 and CKD stage 5 according to the clinical diagnosis. PTH,Cys C,Hcy and Cr were detected in three groups,and the statistical analysis was conducted. Results: The levels of serum PTH,Cys C,Hcy and Cr in CKD stage 5 group were higher than those in CKD stage 4 and CKD stage3 groups,the difference was statistically significant (P <0.05),but there was no significant difference between CKD stage 4 group and CKD stage 3 group in serum PTH,Cys C,Hcy and Cr levels (P >0.05). The positive rates of PTH in CKD stage 5 group,CKD stage 4 group and CKD stage 3 group were: 70.8%,21.4%,20%;The positive rates of Hcy in CKD stage 5 group,CKD stage 4 group and CKD stage 3 group were: 58.3%,7.1%,10%. PTH,Hcy,Cr and Cys C were positively correlated (R = 0.505、0.855、0.788). Conclusion: The combined detection of PTH,Hcy and other indicators is helpful for the diagnosis and judgment of CKD patients,and provides accurate guidance for clinical diagnosis and treatment.