摘要
目的:探讨慢性肾脏病患者甲状旁腺激素(PTH)、同型半胱氨酸(Hcy)等指标检测的临床意义。方法:48例慢性肾脏病患者(CKD)按临床诊断分为CKD3期、CKD4期、CKD5期3组,分别检测3组患者的血PTH、Cys C、Hcy、Cr等指标,并进行统计分析。结果:CKD5期组患者血清PTH、Cys C、Hcy、Cr水平均高于CKD4期、CKD3期组,差异均有统计学意义(P <0.05),但CKD4期组患者血清PTH、Cys C、Hcy、Cr水平与CKD3期组相比均无显著性差异(P>0.05)。PTH在CKD5期、CKD4期、CKD3期组阳性率分别为:70.8%、21.4%、20%; Hcy在CKD5期、CKD4期、CKD3期组阳性率分别为:58.3%、7.1%、10%。PTH、Hcy、Cr与Cys C呈正相关(R=0.505、0.855、0.788)。结论:PTH、Hcy等指标联合检测有利于CKD患者疾病的诊断与病情判断,为临床诊疗提供准确的指导。
Objective: To explore the clinical significance of the detection of PTH and Hcy in patients with the chronic kidney disease. Methods: 48 patients with chronic kidney disease (CKD) were divided into three groups: CKD stage 3,CKD stage 4 and CKD stage 5 according to the clinical diagnosis. PTH,Cys C,Hcy and Cr were detected in three groups,and the statistical analysis was conducted. Results: The levels of serum PTH,Cys C,Hcy and Cr in CKD stage 5 group were higher than those in CKD stage 4 and CKD stage3 groups,the difference was statistically significant (P <0.05),but there was no significant difference between CKD stage 4 group and CKD stage 3 group in serum PTH,Cys C,Hcy and Cr levels (P >0.05). The positive rates of PTH in CKD stage 5 group,CKD stage 4 group and CKD stage 3 group were: 70.8%,21.4%,20%;The positive rates of Hcy in CKD stage 5 group,CKD stage 4 group and CKD stage 3 group were: 58.3%,7.1%,10%. PTH,Hcy,Cr and Cys C were positively correlated (R = 0.505、0.855、0.788). Conclusion: The combined detection of PTH,Hcy and other indicators is helpful for the diagnosis and judgment of CKD patients,and provides accurate guidance for clinical diagnosis and treatment.
作者
刘虹
金娟
周志凤
张白银
郑元杰
陈正徐
曹娟
LIU Hong;JIN Juan;ZHOU Zhifeng(Hefei Second People's Hospital,Anhui Hefei 230011,China)
出处
《河北医学》
CAS
2019年第3期577-580,共4页
Hebei Medicine
基金
江苏省卫生计生委科研课题
(编号:Z201525)