地屈孕酮联合孕三烯酮用于子宫内膜异位症手术治疗患者中效果分析

Analysis of the Effect of Desdrogesterone Combined with Gestrinone in the Surgical Treatment of Endometriosis

目的:分析地屈孕酮联合孕三烯酮用于手术治疗的子宫内膜异位症患者中的效果。方法:选择行保守治疗的子宫内膜异位症患者120例,随机为两组,各60例,对照组用孕三烯酮(内美勇)治疗,观察组加用地屈孕酮治疗。观察组两组治疗前后性激素促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)水平;评估治疗前后视觉模拟疼痛评分(VAS);观察两组患者治疗前后糖类抗原125(CA125)水平变化;对比两组不良反应发生情况、1年复发率。结果:治疗后两组患者FSH、LH、E2水平,痛经、性交痛、慢性盆腔炎分值,CA125水平均低于治疗前(P<0.05);治疗后观察组FSH、LH、E2水平,痛经、性交痛、慢性盆腔炎分值,血清CA125均低于对照组(P <0.05);两组患者不良反应发生率、1年复发率差异无统计学意义(P>0.05)。结论:子宫内膜异位症手术治疗患者联合应用地屈孕酮、孕三烯酮,能更好改善性激素水平,缓解疼痛,降低血清CA125水平,不良反应少,复发率较低,安全可靠值得应用。

Objective: To analyze the effect of desdrogesterone combined with gestrinone in the surgical treatment of endometriosis. Methods: 120 conservative patients with endometriosis were randomly divided into two groups,60 cases in each group. The control group was treated with gestrinone (Nemeyong),while the observation group was treated with didrogesterone. In the observation group,the levels of FSH,LH and E2 before and after treatment,the visual analogue pain score (VAS) before and after treatment,the changes of carbohydrate antigen 125 (CA125) levels before and after treatment,and the incidence of adverse reactions and1-year recurrence rate were compared between the two groups. Results: After treatment,the levels of FSH,LH,E2,dysmenorrhea,sexual intercourse pain,chronic pelvic inflammation and CA125 in the two groups were lower than those before treatment (P <0.05);after treatment,the levels of FSH,LH and E2,dysmenorrhea,sexual intercourse pain,chronic pelvic inflammation and serum CA125 in the observation group were lower than those in the control group (P <0.05). There was no significant difference in incidence and recurrence rate in 1 years (P >0.05). Conclusion: Didrogesterone combined with gestrinone can improve the level of sex hormone,relieve pain,reduce the level of serum CA125 in patients with endometriosis,with fewer adverse reactions and lower recurrence rate. It is safe and reliable to use.