脾边缘区B细胞淋巴瘤临床病理及免疫组化研究

Splenic marginal zone B-cell lymphoma of a clinicopathological and immunohistochemical study

目的探讨脾边缘区B细胞淋巴瘤的临床病理表现和免疫组化表型,为该肿瘤的诊断和治疗提供依据。方法外科手术脾切除标本及淋巴结标本进行常规病理组织学检查,并应用免疫组织化学方法以多种单克隆抗体标记肿瘤细胞。结果肿瘤累及脾白髓边缘区,瘤细胞中等大小,胞质透明,胞核稍不规则。免疫组化LCA+,L26+,CD79α+,bcl-2+,UCHL-1-,CD3-,CD5-,CD10-,Kp-1,CyclinD1-。结论脾边缘区B细胞淋巴瘤为一种极少见的低度恶性B细胞淋巴瘤,可累及淋巴结,根据其临床病理及免疫组化特征可作出诊断。

Objective To investigate the clinico-pathological manifestation and immunophenotype of splenic marginal zone B-cell lymphoma(SMZL),pro-vide reliable basis for diagnosis and treatment ofthe tumor.Mehtods Make a routine pathological histology examination to splenectomy specimens and lymph node specimens in surgical operation,im-munohistochemical method was used to mark tumorcells in the form of monoclonal antibody.Results The tumor involved marginal zone of splenic white pulp,tumor cell is medium size,cytoplasm is trans-parent,and cell nucleus is a little irregular.In im-munohistochemistry,positive for LCA,126,CD79 α .and bcl -2,while negative for UCHL -1,CD3,CD5,CD10,Kp-1and CyclinD1.Conclusion SMZL is a rare low -grade lymphoma,that was involved in lymph node.Make a diagnosis in the basis of its clinico-pathology and immunohistochemistry features.