摘要
目的 探讨妊娠合并甲状腺功能减退症(甲低)的临床监测和治疗方法及母婴状况。 方法 回顾性分析我院1994年1月～2001年1月10例妊娠合并甲低病人临床治疗及母儿情况。孕期每1～1.5月监测一次血TSH、FT_3及FT_4浓度,TSH值高于及FT_3和FT_4值低于正常值时,调整甲状腺素用量;观察妊娠结局;6～24个月随访儿童身高、体重和智力发育。结果早孕期血TSH、FT_3及FT_4浓度与孕前比较,差异无显著性(P<0.05);中、晚孕期血TSH较孕前升高,FT_3、FT_4较孕前降低,中、晚孕期甲状腺素用量较孕前增加,差异有显著性(P<0.05,P<0.01);早孕期用药量为(0.963±0.102)mg/(d·kg),晚孕期为(1.301±0.043)mg/(d·kg),甲状腺素用量增加 35.101％;8例新生儿追踪2年,体格和智力发育正常。结论 定期监测血TSH、FT_3和FT_4浓度,及时调整甲状腺素用量,妊娠结果良好。
Objective To review clinical treatment of hypothyroidism during pregnancy and to follow up the children born to these mothers Methods A retrospective analysis of 10 cases of hypothyroidism during pregnancy and a follow-up were carried out. Results There were no changes in serum concentrtions of TSH, FT3 and FT4 in first trimester compared with serum concentrations of TSH, FT3, and FT4 before pregnancy. However, TSH concentrations was increased and FT3 and FT4 decreased since second trimester. Two-year's follow up to 8 children torn to treated hypothyroidism mothers showed no physical or mental problems. Conclusions Treatment should be adjusted according to levels of serum hypothyroid hormones; Treated properly, the prognosis of the children born to these mothers could be good.
