抗返流治疗对伴胃食管返流哮喘患者肺通气功能的影响

Anti-reflux affecting the pulmonary ventilative function for the treating asthma with gastroesophageal reflux

目的 :探讨抗返流治疗对伴胃食管返流 (GER)哮喘患者肺通气功能的影响。方法 :6 0例GER合并哮喘患者随机分为A、B两组 ,两组患者在常规服用β2 受体激动剂的同时 ,采用单盲法 ,A组口服安慰剂 ,B组口服吗丁啉和雷尼替丁作抗返流治疗 ,4周后测定FVC、FEV1、PEF。结果 :B组肺功能改善明显 ,与A组相比有显著差异 (P <0 .0 5 )。结论 :GER是诱发和加重哮喘的重要因素 ,哮喘合并GER患者作抗返流治疗能有效控制哮喘发作 。

Objective:To explore anti-reflux to asmatic patients with gastroesophageal reflux (GER)affecting asthmatic pulmonary function. Methods:In 60 patients of GER with asthma divided randomly into A?B group,both taking β 2-receptor active agent simultaneously in roution,A taking placebo,B taking domeperidoni and ranitidine for treating anti-reflux,four weeks later measuring FVC?FEV1?FEF?Result: B showing the pulmonary function improvement obviously.There was significant difference comparing with A(P<0.05).Conclusion:GER was the important factor inducing and aggravating asthma,asthmatic patients with GER can be controled effectively and improve the lung ventilative function by anti-reflux treating.