老年糖代谢异常人群冠心病患病率、发病率及其危险因素分析

Analysis of the Prevalence and Inddence of Coronary Heart Disease and Associated Risk Factors in the Elderly with Impaired Glucose Metabolism

目的:对老年人群冠心病(CHD)患病率、发病率及其相关危险因素进行分析研究。方法;健康查体年龄60岁以上的无CHD的老年人群作为基线入群,计算基线时CHD患病率,采用入年法计算其发病率。同时还采用Logistic回归分析对4年中新发的CHD危险因素进行分析。结果:老年人群CHD的发病率为34.26/1000人年,其中IGT和DM组分别为50.42和57.08/1000人年,明显高于NGT组的27.55/1000人年(P<0.05,<0 01)。经Logistic逐步回归分析表明,DM、IGT、高血压(HT)、BMI和年龄与CHD发生明显相关。结论:IGT和DM组的CHD患病率和发病串明显高于NGT组,糖代谢异常、高血压、肥胖和增龄与CHD发病密切相关。

Objective:To evaluate the prevalence and incidence of coronary heart disease (CHD)and associated risk factors with CHD in the elderly. Method: A survey was conducted among old subjects aged 60 to 90 Who had health examination The cohort population without CHD. The prevalence of CHD was calculated at baseline. The incidence of CHD was calculated by person year method. The risk factors of incidence in CHD of different groups were analyzed with multiple logistic regression at the end of four observed years. Result: The prevalence of CHD (67.4% ,70.2% ) and myocardial infarction(MI)(7.5%, 11.2%)of IGT、and DM group were significantly higher than that of NGT group(57.1%, 4.4% )(p<0.05, p<0.01 respectively). There were 875 cases in the cohort population without CHD at baseline. The incidence of CHD was 34.26 per 1, 000 observation person-year in the elderly. The incidence of CHD in IGT and DM group was 50.42 and 57.08 per 1,000 observation person-year, respectively. Both were significatly higher than that of NGT group(27.5/1,000 person-year) (p<0.05, p<0.01). Logistical regression test showed that DM, IGT, hypertension, BMI and age were risk factors related to incidence of CHD. According to ADA criteria, Logistical regression test showed DM, hypertension and age were risk factors related to incidence of CHD Conclusion: According to 1985 WHO criteria, the prevalence and incidence of CHD in IGT and DM group were significantly higher than that of NGT group. The incidence of CHD were associated with risk factors including impaired glucose metabolism, hypertension, obesity and age. According to ADA criteria, the prevalence and incidence of CHD in DM group was significantly higher than that of NFG group, but 1FG was not.