老年糖代谢异常人群死亡率的相关分析

Analysis of Mortality in the Elderly with Impaired Glucose Metabolism

目的:了解老年人群所有原因及心血管疾病的死亡率。分析糖代谢异常对所有原因及心血管疾病死亡率的影响。方法:健康查体年龄60岁以上老年人群为基线人群。糖尿病(DM)诊断按照1985年WHO标准确定,各组累积生存率的估计采用Kaplan-Meier方法和Cox比例风险模型。结果:IGT和DM组心、脑血管疾病每1000人年的死亡率分别为7.55和8.86,明显高于NGT组2.43(P<0.05,P<0.01),经年龄调整IGT和DM组死亡的相对危险度(RR)为2.70(95%CI 1.56-3.81)和2.84(1.57-4.12),其它心血管疾病危险因素调整后的死亡RR为3.14(2.15-5.12)和3.46(2.20-5.23)。结论:老年人群DM和IGT患者.因心血管疾病导致的死亡率明显高于NGT,DM和IGT是导致心血管疾病死亡的重要危险因素。

Objective:To estimate the all-cause and cardiovascular mortality and analyze influence of impaired glucose metabolism on all-cause and cardiovascular mortality in the elderly. Method: A survey was conducted among 2, 239 old subjects aged 60 to 90 who had health examination . DM and IGT were diagnosed according to criteria of WHO in 1985. The cumulative survival rates of different groups were calculated by Kaplan-Meier method and Cox's proportional hazard model. Results:The elderly people were classified into three groups:normal glucose tolerance(NGT)(n=1521), impaired glucose tolerance( IGT) (n=279) and diabetes mellitus( DM) (n=439) at baseline. At the end of four observed years,the mortality of IGT and DM group was 7.55 and 8.86 per 1,000 observation person-year, respectively, both were significanty higher than the mortality(2. 43/1, 000 person-year)in NGT group(P<0.05,0. 01). The relative risk(RR) of mortality in IGT and DM group were 2.7(95%CI1. 56-3.81)and 2.84(1.57-4.12)after adjustment for age, the relative risk(RR)were 3.14(2.15-5.12)and 3.46(2.20-5.23)after further adjustment for other cardiovascular disease risk factors. Conclusion:The mortality of DM and IGT on deaths from cardiovascular disease were significantly higher than that of NGT group. DM and IGT were risk factors causing cardiovascular disease deaths.