放射性核素反义治疗

Radionuclide antisense therapy

放射性核素反义治疗将反义寡核苷酸阻断癌基因表达作用及放射性核素杀伤癌细胞作用结合在一起,是一项新兴的治疗技术。这项研究目前仍处于初步阶段,只有少量放射性寡核苷酸细胞毒性、动物体内药代动力学及组织学分布的报道。简要综述了目标基因的选择和反义寡核苷酸的标记、导入细胞及其毒副作用等几个放射性核素反义治疗有关的重要环节及其最新进展。

Radionuclide antisense therapy achieves the joint goals of antisense therapy and internal radioation therapy.There have been a small number of investigations on the radionuclide antisense therapy in tissue culture and in animal studies.Considerable research is required before this novel technique can become a working practice.We reviewed some question and development on the radionuclide antisense therapy,such as selection of the target gene sequence,labelling the antisense oligonucleotide,improvement of the uptake and target of radionuclide antisense oligonucleotides and evalu-ation of the toxicity of the radionuclide antisense therapy.