微束在辐射诱导的旁效应研究中的应用

The application of microbeam in the research on radiation-induced bystander effects

辐射诱导的旁效应现象近年来已经引起了越来越多的关注,它对于目前低剂量辐射效应的研究将产生重大影响。在其研究过程中,由于电离粒子在能量、径迹上的随机分布,用常规照射的方法无法提供旁效应的直接证据以及准确的单一粒子与生物体的作用结果。微束的发展,特别是单粒子微束通过将精确数量的粒子准确地射入细胞或细胞特定位置,为辐射诱导的旁效应的研究提供了直接有用的手段。为此,论述了辐射诱导的旁效应现象以及微束在其研究中的应用。

There has been more and more attention to the phenomenon known as radiation-induced bystander effects,which will have a tremendous effect on the research in low-dose radiation biological effects.However,due to the stochastic nature of energy deposition and the random position of tracts,direct evidence for bystander effects and exact results of single particle interacts with a cell cannot be provided by using conventional broad -field irradiation.The availability of microbeam,especially the single particle microbeam in the world,whereby individual cells or precise location of cells can be irradiated with either a single or an exact number of particles provides a useful tool for the research on radiation-induced bystander effects.This report describes the radiation-induced bystander effect and the application of microbeam in the research on it.