单纯性肥胖儿童血脂、脂蛋白、载脂蛋白的研究

Serum lipids lipoproteins and apoproteins in simple obese children

目的 通过对单纯性肥胖儿童的血脂、脂蛋白、载脂蛋白进行研究,探讨其发生动脉粥样硬化(As)的危险性。方法 对54名肥胖儿童和60名正常体重儿童分别测定其血清脂质、脂蛋白、载脂蛋白,同时测定腰围、臀围、皮褶厚度,计算腰臀围比(WHR)、体脂百分比(％BF)、脂肪组织(FM)。结果 肥胖组儿童血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)和载脂蛋白B100(apoB100)的浓度高于非肥胖组(P<O.05),而高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AI(apoAI)的浓度却低于非肥胖组,差异有显著性(P<O.05),肥胖组与非肥胖组儿童总胆固醇(TC)浓度差异没有显著性(P>0.05)。结论 单纯性肥胖儿童脂质代谢出现紊乱,肥胖儿童发生AS的危险性增加。

Objective To explore the risk factors of atherosclerosis in simple obese children by measuring serum lipids, lipoproteins and apoproteins levels. Methods Serum lipids, Kpoproteins and apoproteins levels were assayed in 54 obese and 60 non-obese children. At the same time the waist and hip circumference and skin-fold thickness were measured. Waist to hip ratio (WHR) , percentage of body fat(%BF) and body fat mass (FM) were calculated. Results The concentrations of TG, LDL-C, VLDL-C, and apoB1oo in obese children were significantly higher than those in non-obese children ( P < 0.05) , while the concentrations of HDL-C, apoA I in obese children were significandy lower dian diat in non-obese ones (P < 0.05) . No significant difference was found in concentration of TC in drese two groups ( P > 0.05 ) . Conclusion Simple obese children had serum lipids metabolic disorder. It would be a risk factor of adierosclerosis.