感染患者口服氟罗沙星片的药代动力学

Pharmacokinetics of Fleroxacin Tablet in Serum and Urine of Infected Patients

目的:测定氟罗沙星在感染患者体内的药物代谢动力学。方法:HPLC法测定9例患者单剂量口服氟罗沙星200 mg后血清中药物浓度,并计算药代动力学参数。结果:氟罗沙星血清药物浓度-时间曲线符合一级吸收二室模型。药物吸收有一较大滞后时间期,平均为(0.25±0.14)h,吸收相t1/2Ka平均(0.88±0.17)h,消除t1/2β平均(13.22±2.78)h,达峰时间(3.99±0.40)h,药时曲线下面积(13.56±3.98)mg·h/L,消除速率(0.75±0.40)L/h,尿中原型药物24 h排出率为8.00％～13.00％,平均为(10.16±1.46)％,并且集中在8 h以后排出。结论:氟罗沙星片具有长效作用。

Objective: To study the pharmacokinetics of fleroxacin in serum and urine of infected patients. Methods: Single oral dose of fleroxacin tablets 200 rng were given to nine patients in the study, fleroxacin concentrations in serum and urine were determined by high performance liquid chromatography and the parameters were computed with 3P87 program. Results: The concentration - time curves of fleroxacin tablets were conformed to a two compartment open model. The tfag was(0. 25± 0. 14) h, t1/2Ka(0. 88 ±0. 17) h, t1/2β( 13. 22 ±2. 78)h, tpeak(3. 99 0. 40)h, Cmax(0. 94 0. 24)mg/L, AUC0 ∞(13. 56±3. 98) mg ?h/L, and ClKe(0. 75±0. 40) L/h. The discharge rate in 24 h of original fleroxacin urine was (10. 16±1.46)% separately. Conclusion: Fleroxacin tablet was a long acting preparation.