吡喹酮长效缓释棒控制家犬细粒棘球绦虫感染的现场研究

Field investigation of the control of Echinococcus granulosus infection in dogs bysubcutaneously plantation with a sustained slow release preparation of praziquantel

目的 为确定吡喹酮驱虫棒在包虫病现场控制家犬细粒棘球绦虫感染的效果。方法 以吡喹酮 1 6～ 2 5g/犬剂量 ,给家犬皮下埋植。植前测定犬粪抗原。植后测定实验组和对照组犬粪抗原并同时做槟榔碱导泻的方法进行预防效果评价。结果 Ⅰ号药棒埋植后 8个月 ,粪抗原阳性率从埋药前的 19 5 %下降至 4 6 %。槟榔碱导泻结果 ,实验组的成虫感染率比对照组低 5倍以上 ,差异显著。Ⅱ号药棒埋植前犬群粪抗原阳性率为 4 1 3% ,埋植 1年后实验组粪抗原阳性率为 0 9% ,对照组为 36 4 %。结论 Ⅰ号药棒可以保护未感染犬不发生感染 ,但不能完全驱除已感染并寄生的成虫。Ⅱ号药棒实际上可以完全控制家犬细粒棘球绦虫的感染。这种药棒可以做为包虫病预防措施的主要手段 ,在流行地区推广使用。

Aim To determine the efficacy of a sustained slow release drug dar of praziquantel in control of Echinococcus granulosus infection in dogs in the field of endemic areas of cystic echinococcosis Methods subcutaneously planting of the slow release drug bar to dogs with dosage of 1 6g～2 5g/dog of praziquantel The coproantigen in dog feces were detected before and after plantation and the arecoline purgation was taken after planting to assessing the control efficacy of the drug bar in field experiments Results The coproantigen positive rate decreased markedly in planted dogs with the slow release drug bar No Ⅰ,and infection rate of adult worm in planted dogs decreased over five folds than in dogs of control group The E granulosus infection has been controlled completely in dogs planted with the drug dar No Ⅱ,Conclusion The sustained slow release drug bar No.Ⅱ.could be used as the main measurement for cystic echinococcosis control in endemic areas