摘要
目的 :比较单用情绪稳定剂缓释锂与小剂量锂盐并丙咪嗪对双向抑郁的治疗作用。方法 :选择符合CCMD - 2 -R双向抑郁发作的病例随机分组 ,共 4 4例完成了 6周的研究 ,其中锂盐组 2 1例 ,丙咪嗪组 2 3例。在治疗前后 1、2、4、6周分别评定HAMD、CGI量表。结果 :锂盐组的有效率为 80 9% ,丙咪嗪组为 82 6 % ,两组相比没有显著差异 ,丙咪嗪组中口干的发生率明显高于锂盐组 (x2 =5 4 9,P <0 0 1) ,且有 2例发生转躁 ,静止性震颤、心电图异常改变等的发生率两组没有差异。结论 :锂是治疗双向抑郁的有效药 ,没有必要并用抗抑郁剂。
Objective:This study's purpose was to clarify the appropriate treatment of bipolar depression by comparing the imipramin versus mood stabilizer(lithium) Method:44 patients were randomly assigned to groups either received with imipramin or lithium for 6 weeks Results:Both groups showed significant improvement in depressive symptoms during the 6-week trial Differences in overall efficacy between the two groups had no statistically significant Conclusions:Antidepressants may not be useful adjunctive therapy for bipolar depressed patients with lithium
出处
《中国民康医学》
2003年第1期1-2,共2页
Medical Journal of Chinese People’s Health
关键词
双向抑郁
锂盐
丙咪嗪
治疗
Bipolar Depression
Lithium
Imipramin
Treatment