艾灸对宫颈癌放疗患者外周血T细胞亚群的影响

Effect of Moxibustion on Peripheral T-cell Subgroups of Patients with Cancer of Uterine Cervix

目的 探索艾灸对宫颈癌放疗患者T细胞免疫系统的作用。方法 采用单克隆抗体 (MCAb) ,借助APAAP桥联酶标法 ,检测 2组宫颈癌放疗患者外周血T细胞亚群的数量。结果 艾灸治疗 2个月后宫颈癌放疗患者外周血CD3+、CD4 +T细胞数量较艾灸前有明显增加 (P <0 .0 1 ) ,而CD8+T细胞数量下降 ,差异显著 (P <0 .0 5 ) ;空白对照组CD3+、CD4 +T细胞数量下降 ,但尚无显著性差异 (P >0 .0 5 )。同时分别观察了CD4 +/CD8+T细胞的比值 ,艾灸治疗组明显上升 (P <0 .0 5 ) ,而空白组有下降趋势 ,但无显著性差异。

OBJECTIVE To investigate into the effect of moxibustion on the peripheral T-cell subgroups of patients with cancer of the uterine cervix who receive chemotherapy.METHOD Monoclonal antibody (MCAB) and APAAP bridged enzyme labeling method were used to detect the number of peripheral T-cell subgroups.RESULT Two months after the moxibustion treatment, the number of the peripheral blood CD3 and CD 4 + T-cells in the patients receiving chemotherapy for cancer of the uterine cervix increased greatly (P<0.01) and the number of CD 8 + T-cells decreased markedly (P<0.05). In the control group, the number of CD 3 + and CD 4 + T-cells decreased insignificantly (P>0.05).CD 4 + to CD 8 + ratio increased markedly (P<0.05) in the treatment group but decreased in the control group, with no significant difference.CONCLUSION Moxibustion has protecting and immunologically regulating effect on the peripheral T-cells of patients receiving chemotherapy for cancer of uterine cervix.