离子液体中采用AGET ATRP法制备MCC-g-PGMA

Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids

在氯化1-烯丙基-3-甲基咪唑([AMIM]Cl)离子液体中,采用AGET ATRP技术,以VC为还原剂、Cu Br2/乙二胺为催化体系,成功制备了微晶纤维素接枝聚甲基丙烯酸缩水甘油酯(MCC-g-PGMA)分子。研究表明:[AMIM]Cl对微晶纤维素有较好的溶解性,最佳反应条件为GMA/乙二胺/Cu Br2/VC摩尔比为100:4:1:1,反应温度25℃,反应时间4 h,接枝效率可达54.56%,分子量分布较窄为1.48。通过FT-IR、TEM和SEM测试表明:成功合成了MCC-g-PGMA接枝共聚物分子,PGMA接枝微晶纤维素后表面形态变得粗糙,接枝共聚物在丙酮溶液中可自组装成150~200 nm的球形结构,在药物载体领域具有良好的应用潜能。

The MCC-g-PGMA was synthesized by AGET ATRP in ionic liquid [AMIM]Cl. Vitamin C was used as the reducing agent and CuBr2/ethanediamine was the catalytic system. The experiment proved that microcrystalline cellulose can well dissolve in [AMIM]Cl. Optimum mole ratio of GMA/ethanediamine/ CuBr2/VC were attained at 100:4:1:1. The temperature and reaction time were 25℃ and 4 h. The grafting efficiency was as high as 54.56% and the distribution of molecular weight of MCC-g-PGMA was 1.48. FT-IR proved that the MCC-g-PGMA graft copolymer was successfully synthesized by AGET ATRP in [AMIM]Cl. SEM showed the surface of MCC was changed and became coarse after PGMA grafted to MCC. It has a perfect application potential in the field of drug carrier.