体外神经牵延器修复周围神经缺损的实验研究

Experimental study of nerve elongation apparatus for repair of defect of peripheral nerve in vitro

目的 观察体外神经牵拉延长器修复兔周围神经缺损效果,为临床应用提供实验依据。方法 健康成年家兔36只,造成右侧坐骨神经缺损模型,随机分为神经牵拉延长组(12只)、神经游离移植组(12只)和神经端端吻合组(12只)。术后每周观察动物一般情况,第12、16、20周行神经电生理测定,第20周观察组织学变化。结果 神经牵拉延长器组神经功能恢复情况与神经游离移植组无明显差别,优于神经端端吻合组。结论 神经牵延器体外缓慢延长修复周围神经缺损是可行的。

Objective To observe the effect of nerve elongation apparatus in vitro to repair defect of peripheral nerve to provide the basis for the clinical application Methods The peripheral nerve defects were created in right sciatic nerve in 36 healthy rabbits,and they were divided randomly into nerve elongation group (n= 12),nerve graft group(n= 12) and end to end suture group(n= 12). After operation the general condition were observed every week and electro-physiologic testing were observed at 12th, 16th and 20th weeks and histo-pathlogical study were observed at 20th weeks. Results There was no statistical difference observed between nerve elongation group and nerve graft group, and their effect were excellent than end to end suture group. Conclusion The nerve elongation repairing of the peripheral nerve defect in vitro was effective and may be used clinically.