氨基糖苷类抗生素生物合成基因研究进展

Advances in the biosynthesis genes of the aminoglycoside antibiotics

目的对氨基糖苷类抗生素生物合成基因的研究进展作一综述。方法按照化学结构类型 ,分别介绍了有糖苷取代的氨基环己醇类抗生素和 2 脱氧链霉胺类抗生素的生物合成基因的研究状况 ,以及氨基糖苷类抗生素生物合成基因的特点。结果与结论氨基糖苷类抗生素生物合成基因具有很多共同的特点 ,为进一步对氨基糖苷类抗生素生物合成基因进行克隆。

Objective To review the studies on the biosynthesis genes of the aminoglycoside antibiotics.Methods The biosynthesis genes of the antibiotics which contain an aglycone of fully-substituted aminocyclitol and the antibiotics which contain a common aglycone of 2-deoxystreptamine(DOS) were introduced; the characters of the biosynthesis genes of the aminoglycoside antibiotics were also reviewed.Results and Conclusion There are many common characters of the biosynthesis genes of the aminoglycoside antibiotics,which will be a reference to further studies.