神经管畸形的环境危险因素研究进展

Neural tube defects-related environmental risk factors:a review of recent studies

神经管畸形(neural tube defects,NTDs)是出生缺陷中最常见、最严重、病死率最高的缺陷类型,是影响我国出生人口质量的重大公共卫生问题之一。NTDs为多因素复杂性疾病,阐明NTDs发生的作用机制是预防和减少重大出生缺陷发生的关键,也是重大出生缺陷研究的新的发展趋势。该文对NTDs的环境危险因素、代谢组学、表观遗传学研究和预防干预现状进行综述,并对未来研究进行展望。

Neural tube defects(NTDs)are one of adverse pregnancy outcomes with the highest incidence rate and fatality rate,and one of the major public health problems affecting the population quality in China.NTDs are the complex diseases resulting from multi-factors.It is the key problem of birth defects prevention to clarify the mechanism,and a new research field of major birth defects research.The environmental risk factors,metabolic genomics,epigenetics,and research advances on prevention and intervention of NTDs were reviewed in the present paper.