颈椎1号胶囊的制备工艺研究

Study on the Preparation Technology for Jiangzhuiyihao Capsules

目的:确定复方颈椎1号胶囊的工艺制备条件。方法:采用L9(34)正交设计,以总黄酮得率为评价指标,优选出最佳的制备条件,并且考察胶囊辅料的吸湿性。结果:最佳制备工艺是8倍量水回流提取2次,每次1小时,药粉与糊精质量比为2∶1,80%乙醇为润湿材料,其用量约为浸膏粉混合物的10%,临界相对湿度为59.44%。结论:此制备工艺合理稳定,有效成分较多,成本相对较低,可用于颈椎1号胶囊大批量的生产。

Objective:To investigate the optimal extraction process of jingzhuiyihao capsules. Methods:L9(34)orthogonal test was used in optimization of the exsperiment with the rate of compound pyrola as the marker ,and moisture absorption of excipient was studied, which optimize the best extraction process. Results: the best extraction process was as followed:medicine materials were soaked in 8-fold volume of water for twice,1 hour for one time.peanut hulls extract-dextrin=2:1,and 80% ethanol as the moistening agent which amounts to 10% of the mixture,which make the mixture had a critical relative humidity of 59.44% and a good fluidity. Conclusion:the method is stable and reliable, more effective components and economic,suitable for mass production.