血清总Ⅰ型胶原氨基端延长肽和Ⅰ型胶原羧基端肽在骨质疏松症并发骨折检测的临床意义

Clinical Significance of TP1NP and CTX in Osteoporosis and its Complications Such as Tractures

目的:探讨骨形成标志物血清总I型胶原氨基端延长肽(TPINP)和骨重吸收标志物I型胶原羧基端肽(CTX)在骨质疏松症并发骨折患者中临床检测的意义。方法:回顾性分析我院自2013年1月至2014年7月共50例初诊为骨质疏松导致骨折患者的病例资料,并利用罗氏Cobas e411免疫分析仪采用电化学发光法测定血清中TPINP和CTX,采用t检验进行统计学分析骨质疏松导致骨折病人及健康对照组外周血中TPINP和CTX等的表达。结果:和健康对照组相比,骨质疏松导致骨折患者外周血中TPINP及CTX的水平明显增高,TPINP和CTX在骨质疏松及健康对照组的表达分别为94.9±5.49μg/ml及35.06±2.74μg/ml;0.89±0.05μg/ml及0.36±0.02μg/ml;P<0.01,差异有统计学意义。结论:TPINP和CTX可做为骨质疏松及其严重并发症骨折的预防性检测指标及治疗监测有一定的应用价值。

Objective: To investigate the clinical significance of TPINP and CTX in osteoporosis and its complications such as tractures. Methods:A retrospective analysis was conducted on the petients who were initially diagnosed as osteoporosis. A total of 57 patients were inclued for analysis between January 2013 and July 2014. And TPINP and CTX of these patients were detected by Cobas e411. The results were analysis by T test. Results:Compared with controls, the patients of osteoporosis and its complications such as Tractures expressed higher levels of TPINP (94.9±5.49ng/ml and 35.06±2.74ng/m) and CTX (0.89±0.05 ng/ml and 0.36±0.02 ng/ml) (p<0.01). Conclusion:TPINP and CTX may be a noval biomarker for auxiliary diagnosis of osteoporosis and its complications such as tractures and could be useful to understand state of illness.