血小板计数及血浆D-二聚体水平与肺癌相关性研究

The correlations of platelet count and D-dimer level with lung cancer

目的探讨肺癌患者与血小板计数及血浆D-二聚体水平的相关性研究。方法回顾性分析155例肺癌患者及120例健康体检者的血小板计数及血浆D-二聚体水平。结果肺癌患者相比健康体检者,血小板计数[(301.90±61.13)×109/L与(245.30±30.28)×109/L]及血浆D-二聚体水平[406(156.0,969.0)ng/m L与124(58.0,177.0)ng/m L]增高(Z=4.159、P<0.01及Z=15.259、P<0.01),而肺癌患者中,发生远处转移患者相比原位癌患者,血小板计数[(354.32±93.21)×109/L与(271.20±46.49)×109/L]及血浆D-二聚体水平[663(164.5,1 465.5)ng/m L与350(155.5,786.0)ng/m L]进一步增高(Z=4.058、P<0.05及Z=3.155、P<0.05)。结论肺癌患者血小板计数及血浆D-二聚体水平与肺癌转移、预后存在相关性。

Objective To study the correlations of platelet count and D-dimer level with lung cancer .Methods Retrospective analysis of platelet count and plasma D-dimer level in 155 patients with lung cancer and 120 normal healthy controls was presented .Results The platelet count and plasma D-dimer level were significantly higher in lung cancer than in normal controls [ ( 301.90 ± 61.13 )×109/L vs (245.30±30.28)×109/L, Z=4.159,P<0.01 and 406(156.0,969.0) ng/mL vs 124(58.0,177.0)ng/mL, Z=15.259,P<0.01].Moreover, the platelet count and plasma D-dimer level were further higher in patients with distant metastasis of lung cancer than in patients with carcinoma in situ [(354.32±93.21)×109/L vs (271.20±46.49)×109/L, Z=4.058, P<0.05 and 663(164.5,1 465.5) ng/mL vs 350(155.5,786.0) ng/mL, Z=3.155, P<0.05)].Conclusion The platelet count and plasma D-dimer level in patients with lung cancer was associated with disease progression and prognosis .