彩色多普勒超声及超声造影在乳腺癌新辅助化疗疗效评估中的价值

The value of color Doppler ultrasound and contrast-enhanced ultrasound in assessment of neoadjuvant chemotherapy in breast cancer

目的探讨彩色多普勒超声及超声造影对乳腺癌新辅助化疗(neoadjuvant chemotherapy,NAC)疗效评估中的应用价值。方法选取2014年1月—2015年6月收治的行NAC乳腺癌患者60例,分别于NAC前和NAC后应用彩色多普勒超声记录病灶大小、血流分级、血流阻力指数等指标;对其中26例行超声造影检查患者记录造影相关参数,包括造影剂到达肿瘤的时间、达峰时间及峰值强度。根据NAC前、后各项指标变化情况评估NAC疗效。结果 NAC后病灶最大径、形态、边界、周边晕带、内部回声变化、血流分级及血流阻力指数均较NAC前差异有统计学意义(P<0.05)。NAC后造影相关参数到达肿瘤的时间、达峰时间及峰值强度均较NAC前有明显变化,差异有统计学意义(P<0.05)。结论超声造影可以通过检测乳腺癌NAC前、后各项指标变化情况,准确评估NAC疗效。

Objective To investigate the value of color Doppler ultrasound and contrast-enhanced ultrasound evaluation of the efficacy of neoadjuvant chemotherapy( neoadjuvant chemotherapy,NAC) in breast cancer. Methods This study included 60 breast cancer patients who received NAC and surgical treatment between January 2014 to June 2015. Tumor sizes,blood flow grading,resistance index( RI) and other related indicators were recorded before and after chemotherapy using color Doppler ultrasound. Of which 26 patients were examined by contrast-enhanced ultrasound and recorded relevant parameters,which including arrival time,time to peak and peak intensity,the efficacy of NAC was assessed according to the change of before and after chemotherapy. Results The maximum lesion diameter,shape,border,surrounding halo zone,change internal echo,blood flow grading and RI values after NAC had significant changes than before( P < 0. 05). The AT,TTP and PI after NAC had significant difference than before( P < 0. 05). Conclusion Contrast-enhanced ultrasound can detect changes in the indicators NAC before and after chemotherapy in breast cancer cases and accurately assess the efficacy of NAC.