摘要
细胞自噬是真核生物体内广泛存在的一种自我保护机制,主要通过降解受损或有害蛋白,或清除体内病原体等,达到保护机体免于伤害的作用这种类似于细胞凋亡的保护机制是否无时无刻都发挥着保护功能,细胞自噬在妇科恶性肿瘤(宫颈癌、卵巢癌和子宫内膜癌等)中有着怎样的改变,这些变化对肿瘤细胞有怎样的影响,作者就细胞自噬和妇科恶性肿瘤的关系进行阐述,了解最新的研究进展和方向,并探讨可行的自噬治疗方法。
Autophagy is a common self-defended mechanism in all the eukaryotes,and it protects cells or organs from the noxious protein and the pathogen by degrading.Does the autophagy plays positive effect in the tissue all the time that similarly to the apoptosis,what happens between autophagy and gynecologic cancers(cervical cancer,ovarian cancer,endometrial cancer),and the influence on the tumorigenesis and progression were unknown.This review illustrates the function of autophagy in the gynecologic cancers,and describes the latest development and therapy schedule about autophagy.
出处
《转化医学杂志》
2017年第1期51-54,共4页
Translational Medicine Journal
基金
"十二五"国家科技支撑计划项目(2012BAI32B05)
关键词
自噬
宫颈癌
卵巢癌
子宫内膜癌
Macroautophagy
Cervical cancer
Ovarian cancer
Endometrial cancer
