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替格瑞洛在急性ST段抬高型心肌梗死患者PCI术中的应用研究 被引量:4

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摘要 目的探讨替格瑞洛在急性ST段抬高型心肌梗死患者PCI术治疗中的应用价值。方法选取2017年1月-2017年9月就诊的行PCI术治疗打的急性ST段抬高型心肌梗死患者80例,随机分为替格瑞洛组40例(实验组),氯吡格雷组40例(对照组),实验组术前给予替格瑞洛180 mg+阿司匹林300 mg口服,术后给予常规剂量双抗,对照组术前给予氯吡格雷600 mg+阿司匹林300 mg口服,术后给予常规剂量双抗。观察两组患者"罪犯"血管术后即刻TIMI3级血流、术后2 h心电图ST段回落情况、住院期间出血情况、术后6个月心脏超声左室舒张末期内径、术后6个月左室射血分数、术后6个月MACE(胸痛、再发心肌梗死、靶血管血运重建、心源性死亡)率。结果实验组患者术后即刻TIMI3级血流恢复率、术后2 h心电图回落率、术后6个月心功能恢复情况明显优于对照组,组间比较差异有统计学意义,住院期间出血事件发生率及术后6个月MACE事件发生率明显低于对照组,组间比较差异有统计学意义。结论替格瑞洛在行PCI术的急性ST段抬高型心肌梗死患者的治疗中,具有较高的临床应用价值,可以改善患者心肌灌注情况,提高患者心功能,降低术后个月MACE事件及出血事件的发生率。
作者 段秋艳
出处 《航空航天医学杂志》 2019年第2期201-203,共3页 Journal of Aerospace medicine
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