3-氯-2′-溴苯丙酮的合成研究

Study on the Synthesis of 3-chloro-2′-bromopropiophenone

考察了各因素对 3 -氯苯丙酮与溴单质反应生成 3 -氯 -2′-溴苯丙酮的反应的影响 ,结果表明 ,以二氯甲烷为溶剂、3 -氯苯丙酮与溴摩尔比为 1∶ 1 ,催化剂 HD2 0 0 1用量为 1 % ,溴滴加时间为 1 h,常温反应是最佳反应条件 ,产物纯度达98.83 % ,收率达 96.1 %。

The influence factors of bromine as brominating agent in the bromo-reaction of 3-chloropropiophenone were investigated.When 3-chloropropiophenone reacted with bromine in 1∶1 molar ratio at room temperature in the presence of HD2001,the yield of the target product was 96.1% with a purity of 98.83%.