氯化胆碱合成反应的模拟及工艺条件优化

Study on the Technological Conditions of the Synthesis of Choline Chloride with Mathematical Model

藉助环氧乙烷与三甲胺盐酸盐反应合成氯化胆碱的反应动力学方程 ,建立了反应的数学模型 ,利用此模型研究了工艺条件、反应器内流动特性对反应的影响规律 ,得到合适工艺条件为 :原料摩尔配比 n EO∶n TMACl=1.0 5～ 1.10∶ 1.0 0 ;反应温度 6 0～ 70℃ ;反应器级数为 2～ 3级 ,停留时间 10～ 2 0 min,与实验结果基本一致。

Choline chloride was synthesized with ethylene oxide and trimethylamine hydrochloride. A mathematical model of the reaction was set up based on the kinetic equation. The influence laws of operation conditions on the reaction were discussed with this model. The optimal reaction conditions obtained are that the mole ratio of EO to TMAHCl is 1.05~1.10∶1.00, the reactive temperature is 60～70℃, the numbe of reactor is 2~3. the reactive time is 10~20 min; The calculation results are satisfactory to the experiment results.