(Z)-2-(4-氟苯氧基甲基)-2-戊烯-γ-内酯和(Z)-2-(4-氟苯氧基亚甲基)-γ-戊内酯的简便合成

A facile synthesis of (Z)-2-(4-fluorophenoxy methylene)-γ-pentanolide and (Z)-2-(fluorophenoxy methyl)-2-penten-γ-lactone

以 3 -(4-氟苯氧基 )丙炔为原料经 5步反应合成了 (Z) -2 -(4-氟苯氧基甲基 ) -2 -戊烯 -γ-内酯和 (Z) -2 -(4-氟苯氧基亚甲基 ) -γ-戊内酯。合成的关键步骤是在 TMSCl/Na I/H2 O/CH3CN体系中化合物 5 -(4-氟苯氧基 ) -3 -戊炔 -2

The synthesis of (Z)-2-(4-fluorophenoxy methylene)-γ-phentanolide (9) and (Z)-2-(4-fluorophenoxy methyl)-2-penten-γ-lactone(8) from 3-(4-fluorophenoxy) propyne(1) in 5 steps has been described.The one pot deconjugation and hydroiodination of 3 with a reagent system of TMSC1/NaI/H 2O in CH 3CN was the key step.