几种手性α-乙酰氨基-β-芳基丙烯酸类化合物的合成

Synthesis of new types of chiral α-acetylamino-β-aryl acrylic acid compounds

以乙酰甘氨酸和苯甲醛及其衍生物为原料 ,合成了一系列含碳碳双键的前手性底物 ,(Z) -2 -乙酰氨基苯丙烯酸、(Z) -2 -乙酰氨基 -3 -(对甲氧苯基 ) -丙烯酸、(Z) -2 -乙酰氨基 -3 -(对氯苯基 ) -丙烯酸、(Z) -2 -乙酰氨基 -3 -(间氯苯基 ) -丙烯酸、(Z) -2 -乙酰氨基 -3 -(间硝基苯基 ) -丙烯酸。后 4种是新的有机化合物。产物结构经过核磁共振。

Through the reaction of acetylaminoacetic acid with benzaldehyde,and its derivatives,a series of pre-chiral substrates including CC double bond were synthesized;(Z)-2-acetylamino phenyl acrylic acid,(Z)-2-acetylamino-3-(p-methoxyphenyl) acrylic acid,(Z)-2-acetylamino-3-(p-chloro-phenyl) acrylic acid,(Z)-2-acetylamino-3-(m-chloro-phenyl) acrylic acid,and (Z)-2-acetylamino-3-(m-nitro-phenyl) acrylic acid.All the above compounds except the first one are new organic compounds.The products were proved right by unclear magnetic resonance and mass spectrometry.