住院中年阻塞性睡眠呼吸暂停低通气综合征患者认知功能特点及影响因素分析

Characteristics and influencing factors of cognitive function among middle-aged inpatients with obstructive sleep apnea-hypopnea syndrome

目的探讨住院中年阻塞性睡眠呼吸暂停低通气综合征患者的认知功能特点及其影响因素。方法运用便利抽样法,选取348例住院中年阻塞性睡眠呼吸暂停低通气综合征患者为研究对象。采用蒙特利尔认知评估量表对其认知功能进行评估,根据得分分为认知功能正常组与认知功能障碍组,对比分析中年阻塞性睡眠呼吸暂停低通气综合征患者的认知功能特点,并应用多因素Logistic回归法分析其影响因素。结果住院中年阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍发生率为39.66%,认知功能障碍组延迟记忆、注意力与认知功能正常组比较,差异有统计学意义(均P<0.01)。Logistic回归分析结果显示,年龄、学历、体育锻炼频次、平均血氧饱和度是患者发生认知功能障碍的影响因素(均P<0.01)。结论住院中年阻塞性睡眠呼吸暂停低通气综合征患者存在较严重的认知功能损伤,其中以延迟记忆及注意力领域受损为主;认知功能障碍的发生与年龄偏大、学历偏低、体育锻炼不足、血氧饱和度偏低有关。

Objective To explore the characteristics and influencing factors of cognitive function among middle-aged inpatients with Obstructive Sleep Apnea-hypopnea Syndrome(OSAHS).Methods Totally 348 middle-aged OSAHS inpatients were recruited using convenience sampling,then Montreal Cognitive Assessment Scale(MoCA)was utilized to assess their cognitive function,and the patients were divided into a cognitive normal group and a cognitive impairment group according to their MoCA score,the characteristics of cognitive function among middle-aged OSAHS inpatients were analyzed comparatively,and its influencing factors were determined using multivariate logistic regression analysis.Results The incidence of cognitive impairment was 39.66%in middle-aged OSAHS inpatients.There were significant differences in delayed recall and attention between the two groups(P<0.01 for both).Logistic regression analysis revealed that,age,educational background,frequency of physical exercise and mean oxygen saturation were the influencing factors of cognitive impairment in middle-aged OSAHS inpatients(P<0.01 for all).Conclusion Cognitive impairment is serious in middle-aged OSAHS inpatients,especially in the area of delayed recall and attention.And cognitive impairment has something to do with patients′older age,lower educational background,inadequate physical exercise and low oxygen saturation.